Written by: adminCalnam Wordpress Theme Pack

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April 2009
16.04.2009

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Written by: adminHormone Replacement Therapy Virtual Symposium

1. According to STRAW nomenclature, late perimenopause is described as a stage when
Changes in menstrual cycle length are greater than 7 days
Menstrual flow is reduced, with changes in cycle length greater than 10 days
Two or more menstrual cycles are skipped
Two or more menstrual cycles are skipped, and there is at least 1 period of amenorrhea exceeding 60 days
Menstrual flow is reduced, with changes in cycle length greater than 10 days, and 2 or more menstrual cycles are skipped
2. Which of the following conditions is NOT directly associated with menopausal changes?
Irritability
Eczema
Bone loss
Insomnia
Joint pain/achiness
3. Based on evidence from the SWAN study, choose the correct descending order for risk of developing hot flashes.
African American > Hispanic > Caucasian > Japanese
African American > Caucasian > Hispanic > Japanese
Hispanic > Japanese > Caucasian > African American
Caucasian > Japanese > Hispanic > African American
None of the above
4. Which of these factors relates to hot flash frequency?
Cold temperature
BMI greater than 27
Cycling and swimming
Eating soy products
All of the above
5. Which of the following conditions may cause hot flashes?
Thyroid disease
Use of tamoxifen
Pancreatic tumors
Autoimmune disease
All of the above
6. According to the WHI study, the cumulative hazard for CHD risk in the use of estrogen therapy is age dependent. Which of the following statements is true?
Conjugated equine estrogen (CEE) administered to women 50-59 years of age lowered the CHD risk at baseline
CEE administered to women 60-69 years of age lowered the CHD risk at baseline
CEE administered to women 70-79 years of age lowered the CHD risk at baseline
CEE administered to women 50-59 and 60-69 years of age lowered the CHD risk at baseline
CEE administered to women 60-69 and 70-79 years of age lowered the CHD risk at baseline
7. Transdermal hormone therapy may have particular advantages for women
With elevated triglycerides
With type 2 diabetes
Who smoke
Who prefer nondaily therapy
All of the above
8. Transdermal hormone therapy differs from oral formulations in the following aspects:
Transdermal formulations avoid first-pass liver metabolism
Transdermal formulations use higher doses than oral formulations
Transdermal formulations cause increased thromboembolism compared with oral formulations
Transdermal formulations provide more stable circulating levels of hormone
Transdermal formulations avoid first-pass liver metabolism, and transdermal formulations provide more stable circulating levels of hormone
All of the above
9. Among the nonhormonal pharmacotherapies, which of the following drugs offers the most effective relief for vasomotor symptoms?
Venlafaxine
Gabapentin
Clonidine
Methyldopa
Bellergal
10. Select the alternative treatment approach(es) that is/are known to reduce vasomotor symptoms.
Paced respiration
Cooling body temperature
Moderate exercise
Relaxing activities
All of the above

Answers:

According to STRAW nomenclature, late perimenopause is described as a stage when
Answer: Two or more menstrual cycles are skipped, and there is at least 1 period of amenorrhea exceeding 60 days
Which of the following conditions is NOT directly associated with menopausal changes?
Answer: Eczema
Based on evidence from the SWAN study, choose the correct descending order for risk of developing hot flashes.
Answer: African American > Hispanic > Caucasian > Japanese
Which of these factors relates to hot flash frequency?
Answer: BMI greater than 27
Which of the following conditions may cause hot flashes?
Answer: All of the above
According to the WHI study, the cumulative hazard for CHD risk in the use of estrogen therapy is age dependent. Which of the following statements is true?
Answer: Conjugated equine estrogen (CEE) administered to women 50-59 years of age lowered the CHD risk at baseline
Transdermal hormone therapy may have particular advantages for women
Answer: All of the above
Transdermal hormone therapy differs from oral formulations in the following aspects:
Answer: Transdermal formulations avoid first-pass liver metabolism, and transdermal formulations provide more stable circulating levels of hormone
Among the nonhormonal pharmacotherapies, which of the following drugs offers the most effective relief for vasomotor symptoms?
Answer: Venlafaxine
Select the alternative treatment approach(es) that is/are known to reduce vasomotor symptoms.
Answer: All of the above

Written by: adminClostridium difficile Infection in Long-Term Care

1. The NAP1 strain of Clostridium difficile is known to produce large quantities of which of the following toxins?
Toxin A
Toxin B
Both toxins A and B
Neither toxin A nor B
2. Although multiple strains of C. difficile may be present in a long-term care facility (LTCF) at any given time, most colonized patients in these facilities remain asymptomatic.
True
False
3. In the absence of adequate eradication methods, C. difficile spores have the potential to survive on the surfaces of inanimate objects for a maximum of which of the following durations?
Hours
Days
Weeks
Months
4. Recent use of which of the following antimicrobials is not commonly associated with an increased risk of C. difficile infection (CDI)?
Aminoglycosides
Ampicillin
Cephalosporins
Fluoroquinolones
5. Which of the following is the most sensitive test for C. difficile?
Assay for detection of glutamate dehydrogenase
Enzyme immunoassay for toxins A and B
Stool culture
Tissue culture cytotoxicity
6. Testing for C. difficile or its toxins should be performed only on unformed stool unless ileus is suspected.
True
False
7. Which of the following is not a marker for severe CDI?
Increased serum creatinine concentration
Increased serum albumin concentration
Presence of colonic thickening on CT scan
Presence of pseudomembranes on endoscopy
8. Recent prospective trials have shown that metronidazole is superior to vancomycin for treatment of severe initial episodes of CDI.
True
False
9. Approximately what percentage of patients who receive treatment for CDI will go on to experience at least one recurrence of symptoms?
10%
20%
30%
40%
10. Which of the following infection control strategies have been found to effectively reduce rates of C. difficile transmission?
Soap and water hand hygiene
Cohorting of patients with known CDI
Restricted use of cephalosporins and fluoroquinolones
All of the above

Answers:

The NAP1 strain of Clostridium difficile is known to produce large quantities of which of the following toxins?
Answer: Both toxins A and B
The severity of infections caused by the BI/NAP1/027 strain may possibly be explained by its capacity to produce large quantities of both toxins A and B.
Although multiple strains of C. difficile may be present in a long-term care facility (LTCF) at any given time, most colonized patients in these facilities remain asymptomatic.
Answer: True
Multiple strains of C. difficile may be present in LTCFs, due in part to the large number of patients who are either colonized at the time of admission or become colonized during their stay; however, relatively few of these patients become symptomatic.
In the absence of adequate eradication methods, C. difficile spores have the potential to survive on the surfaces of inanimate objects for a maximum of which of the following durations?
Answer: Months
Epidemiologic studies have found that C. difficile spores can survive for several months on such surfaces as toilet seats, bedpans, and telephones.
Recent use of which of the following antimicrobials is not commonly associated with an increased risk of C. difficile infection (CDI)?
Answer: Aminoglycosides
One of the main risk factors for CDI remains use of antimicrobial therapy within the previous 6 to 8 weeks. Fluoroquinolones have been most frequently associated with CDI, but other classes that have been implicated include cephalosporins, sulfonamides, macrolides, and some penicillins. To date, the use of aminoglycosides has not been commonly associated with an increased risk for CDI.
Which of the following is the most sensitive test for C. difficile?
Answer: Stool culture
The enzyme immunoassay is less sensitive than the tissue culture cytotoxicity and glutamate dehydrogenase assays. When performed properly, the stool culture is the most sensitive of the tests available for widespread use.
Testing for C. difficile or its toxins should be performed only on unformed stool unless ileus is suspected.
Answer: True
Persistent diarrhea is the most prominent symptom of CDI, so testing patients for C. difficile is recommended when clinical suspicion is high and when the patient has three or more unformed stools within 24 hours for 2 days or longer. However, on rare occasions, a patient with ileus may have CDI without having loose stools or diarrhea.
Which of the following is not a marker for severe CDI?
Answer: Increased serum albumin concentration
In addition to severe diarrhea and marked leukocytosis, markers for severe CDI include increased serum creatinine concentration, decreased serum albumin concentration (less than 2.5 g/dL), colonic thickening and ascites on CT scan, and pseudomembranes on endoscopy.
Recent prospective trials have shown that metronidazole is superior to vancomycin for treatment of severe initial episodes of CDI.
Answer: False
Data reported by Zar et al. suggested that vancomycin may be superior to metronidazole for treatment of cases of severe CDI. For mild cases, response rates for metronidazole and vancomycin were found to be similar.
Approximately what percentage of patients who receive treatment for CDI will go on to experience at least one recurrence of symptoms?
Answer: 20%
Approximately 20% of patients treated for CDI will go on to experience a recurrent episode. Of those who have recurrence of symptoms, 45% are likely to have at least one more future episode.
Which of the following infection control strategies have been found to effectively reduce rates of C. difficile transmission?
Answer: All of the above
Soap and water have been shown to be more effective than alcohol-based sanitizing gels for removing C. difficile spores from hands. Patients with suspected or confirmed CDI should be isolated in private rooms when possible or cohorted if private rooms are not available. Reducing the use of cephalosporins and fluoroquinolones has also been shown to control high rates of CDI in hospitals and LTCFs.

Written by: adminTobacco Use and Dependence

1. Case Study: Michael

Michael is a 24-year-old man. He presents in the clinic with a severe productive cough, shortness of breath, and increased temperature x 3 days. He had 2 previous diagnoses of acute bronchitis. Family history includes his mother, with a recent diagnosis of emphysema, and his father, who died of lung cancer. Both of Michael’s siblings smoke. He is presently dating a smoker. On physical exam his BP is 138/76, pulse 90, respirations 22, and temperature 101.1° F. His lungs have diffuse rhonchi and he has a cough, which is productive of purulent sputum. His smoking history indicates that he has smoked 2 packs of cigarettes per day for 8 years. He has his first cigarette immediately after waking. He tried to quit last year using the patch but was only able to remain abstinent for 2 days. His girlfriend smokes but may be willing to quit smoking with him.

Which ONE of the following statements is true?
Michael’s failure to quit on his first attempt indicates that he will be unlikely to successfully quit in the future
Michael should be treated for his acute illness and smoking cessation should be addressed at a subsequent visit
Michael should be treated for his acute illness. The risk to smokers of acute respiratory infections should be highlighted, and he should be asked if he is willing to quit at this time.
It is inappropriate to continue to discuss Michael’s smoking, as he is already aware of health implications from the media and from his parents’ health history
2. Case Study: Maria

Maria is a 27-year-old woman who presents in the clinic having just learned that she is pregnant. She has no significant medical history and had recently discontinued oral contraceptives. She has been married for 3 years to a nonsmoker. She and her husband are pleased about starting a family. She works as a computer programmer. On physical exam she has a BP of 114/70, pulse 70. Smoking history indicates that she smokes 10-15 cigarettes per day, has smoked for 5 years, and smokes her first cigarette within 30 minutes after waking. She only smokes outside the home and has never tried to quit. Her husband is encouraging her to quit.

You have ASKED Maria about her tobacco use and ADVISED her to quit, stressing the impact of smoking on her pregnancy. Your ASSESSment indicates that she is ready to make a serious quit attempt now. Which of the strategies would NOT be appropriate to ASSIST her in her quit attempt?
Ask Maria how she feels about quitting and listen to her concerns
Set a quit date after which she should not smoke, not even a puff
Discuss with Maria the importance of quitting now for a healthy pregnancy and for the health of her child
Encourage Maria to decrease her cigarettes to 5 or less per day
3. It is important to ARRANGE follow-up contact. Which ONE of the following strategies would be MOST helpful to Maria?
Give her a pamphlet about quitting smoking
Arrange a follow-up visit with the clinic nurse within a week after her quit date
Schedule a follow-up visit in 2 months to check on her quit status
Tell her to call your office if she has any questions
4. Case Study: Joseph

Joseph is a 42-year old male who has visited his dentist complaining of a loose tooth. Examination reveals that Joseph has bone loss consistent with moderate to severe periodontal disease. Further examination reveals that Joseph has numerous mobile teeth and some missing teeth. His health history reveals that he smokes 1.5 packs of cigarettes per day and has a history of hypertension and type 2 diabetes. Joseph and his dentist have previously discussed the link between periodontal disease and his oral systemic health issues. Joseph states he is interested in quitting.

What can Joseph’s dentist do to initially help him determine the best ways to quit smoking?
Provide Joseph with the state quit line number and advise him to contact them for help to support his quit attempt
Review cessation medications options and offer to prescribe medications to support his quit attempt.
Review the oral health benefits of quitting, provide brief counseling, and offer Joseph treatment plan options based on his cessation decision
All of the above
5. Indicate which of the phrases below is MOST ACCURATE to complete the following sentence:

Relapse prevention strategies, such as encouragement, discussions of the benefits of quitting, and assessment of potential challenges to staying quit, should be used with
Heavy smokers who smoke more than 20 cigarettes per day
Tobacco users who have already had several failed quit attempts
Persons using only spit tobacco
Former tobacco users, in particular those who have quit recently
6. Case Study: Tonya

Tonya is a 22-year-old woman who presents at the clinic for a pre-employment physical. She has never been hospitalized and has no current medical problems. Her birth parents are both living and are in apparent good health. She is unmarried with no children. She is concerned about her weight and performs aerobic exercises 3-4 times weekly. She is 5′3″, weighs 120 lb, BP 126/70, pulse 66. Smoking history indicates that she has smoked 20-25 cigarettes per day for 5 years, and smokes her first cigarette 1-2 hours after waking. She tried to stop smoking 1 year ago but relapsed after gaining 7 lb. She states that she feels that being overweight is as bad for her as smoking. Tonya is starting a new job in 2 weeks in a smoke-free office. She would like to stop smoking and has some confidence in her ability to stop.

Which of the following interventions would be most appropriate in assisting Tonya with quitting?
Deny the impact of weight gain
Assist Tonya in establishing a strict diet and exercise regimen
Consider the use of cessation medications that delay weight gain
Refer Tonya for hypnosis because she failed her first quit attempt
7. Case Study: Jackson

Jackson is a 32-year-old man who comes to the clinic with a sore throat x 1 week, and also complains of muscular aches and pains. He has an unremarkable medical history. His mother has adult-onset diabetes and his father has hypertension. He is married with 3 children. Findings on physical exam: temperature 99.9°, BP 146/88, pulse 80, respirations 18. Throat slightly erythematous. Jackson smokes 1.5 packs per day and smokes his first cigarette immediately upon rising. He has no previous quit attempts. He is not interested in stopping but is somewhat confident that he could if he tried.

Which of the following statements is NOT true regarding the intensity of providing treatment for Jackson?
Only intensive treatment programs are effective
Even a 3- to 10-minute intervention can be effective
Brief treatment is more effective than no treatment
Intensive treatment is more effective than brief treatment
8. Which of the following approaches would be MOST helpful to motivate Jackson to consider quitting smoking?
Remind Jackson what smoking is going to do his health if he continues smoking
Encourage him to examine his relationship to tobacco
Provide a motivational intervention designed to enhance future quitting
Set a quit date for Jackson
9. Case Study: Sam

Sam is a 71-year old man currently hospitalized with a diagnosis of emphysema. He has been treated for coronary artery disease since age 50 with statins and daily aspirin. Over the past several years, he has experienced mild dyspnea with exercise, which he has attributed to “aging”. He was admitted following complaints of worsening dyspnea and increased cough with yellow sputum production for the last several months. A 100 pack-year smoker, he has tried to quit numerous times in the past and once succeeded in not smoking for a full year. His physical exam demonstrated mild tachypnea and lungs that demonstrate ronchi. He is obviously worried about this hospitalization and suggests to his doctor that maybe his smoking is responsible for his worsening health; but he feels that it is too late for him to try quitting.

Which of the following strategies would be MOST appropriate for Sam?
Provide Sam with quit smoking self-help materials to read while hospitalized
Recommend that Sam call his community quit smoking group after discharge
Provide assistance, encouragement to quit, and cessation medication while hospitalized and arrange for followup before Sam’s discharge
Focus on treating his current medical condition and strongly recommend that Sam try quitting again after his discharge
10. Which one of the following drugs has been found to be safe and effective for the treatment of tobacco dependence and has been approved for that use by the US Food and Drug Administration (FDA)?
Nortriptyline
Nicotine patch
Nicotine sublingual tablet
Clonidine
11. Case Study: Grace

Grace is a 3 year-old whose mother brings her to the pediatric nurse practitioner because of recurrent upper respiratory infections and several episodes of a nonproductive cough in the past month after Grace is in bed. Grace has had no hospitalizations or emergency department visits. She has met developmental milestones and appears happy and healthy. Vital signs are: temperature 98.6 F, respiratory rate 17, heart rate 82, and BP 118/60. Chest sounds are clear. Family history reveals that that both of Grace’s parents smoke, both inside and outside of the house and, occasionally in the car.

Which of the following would be an appropriate strategy at this time?
Refrain from discussing parental smoking since neither of them are your patient
Suggest that the parents smoke only outside the home
Mention that some states are making it illegal to smoke in cars with a child under age 15
Provide information on secondhand smoke exposure and offer the parents help in preparing for a quit attempt

Answers:

Case Study: Michael

Michael is a 24-year-old man. He presents in the clinic with a severe productive cough, shortness of breath, and increased temperature x 3 days. He had 2 previous diagnoses of acute bronchitis. Family history includes his mother, with a recent diagnosis of emphysema, and his father, who died of lung cancer. Both of Michael’s siblings smoke. He is presently dating a smoker. On physical exam his BP is 138/76, pulse 90, respirations 22, and temperature 101.1° F. His lungs have diffuse rhonchi and he has a cough, which is productive of purulent sputum. His smoking history indicates that he has smoked 2 packs of cigarettes per day for 8 years. He has his first cigarette immediately after waking. He tried to quit last year using the patch but was only able to remain abstinent for 2 days. His girlfriend smokes but may be willing to quit smoking with him.

Which ONE of the following statements is true?
Answer: Michael should be treated for his acute illness. The risk to smokers of acute respiratory infections should be highlighted, and he should be asked if he is willing to quit at this time.
Even brief advice to quit by a clinician results in greater quit rates. Smokers cite a clinician’s advice to quit as an important motivator for attempting to stop smoking. Therefore, clinicians should urge all tobacco users to quit. This advice should be clear and strong. For example, “As your physician, I must tell you that the most important thing you can do to improve your health is to stop smoking.”
Case Study: Maria

Maria is a 27-year-old woman who presents in the clinic having just learned that she is pregnant. She has no significant medical history and had recently discontinued oral contraceptives. She has been married for 3 years to a nonsmoker. She and her husband are pleased about starting a family. She works as a computer programmer. On physical exam she has a BP of 114/70, pulse 70. Smoking history indicates that she smokes 10-15 cigarettes per day, has smoked for 5 years, and smokes her first cigarette within 30 minutes after waking. She only smokes outside the home and has never tried to quit. Her husband is encouraging her to quit.

You have ASKED Maria about her tobacco use and ADVISED her to quit, stressing the impact of smoking on her pregnancy. Your ASSESSment indicates that she is ready to make a serious quit attempt now. Which of the strategies would NOT be appropriate to ASSIST her in her quit attempt?
Answer: Encourage Maria to decrease her cigarettes to 5 or less per day
Strategies that clinicians can use in assisting patients to quit smoking include asking how they feel about quitting, setting a quit date with them, and discussing the positive effect that quitting will have on their families.
It is important to ARRANGE follow-up contact. Which ONE of the following strategies would be MOST helpful to Maria?
Answer: Arrange a follow-up visit with the clinic nurse within a week after her quit date
Follow-up contact should begin soon after the quit date, preferably during the first week. A second follow-up contact is recommended within the first month. Schedule further follow-up contacts as indicated.
Case Study: Joseph

Joseph is a 42-year old male who has visited his dentist complaining of a loose tooth. Examination reveals that Joseph has bone loss consistent with moderate to severe periodontal disease. Further examination reveals that Joseph has numerous mobile teeth and some missing teeth. His health history reveals that he smokes 1.5 packs of cigarettes per day and has a history of hypertension and type 2 diabetes. Joseph and his dentist have previously discussed the link between periodontal disease and his oral systemic health issues. Joseph states he is interested in quitting.

What can Joseph’s dentist do to initially help him determine the best ways to quit smoking?
Answer: All of the above
Physicians, dentists, nurses, physician assistants, pharmacists, or other healthcare professionals are uniquely poised to intervene with patients who use tobacco. The Public Health Service Guideline Treating Tobacco Use and Dependence 2008 Update emphasizes the importance of treating all patients who use tobacco at every healthcare clinic. This Guideline is directed toward clinicians, allied health professionals, healthcare insurers, purchasers, and administrators and sets a new standard of care for smoking cessation treatment.
Indicate which of the phrases below is MOST ACCURATE to complete the following sentence:

Relapse prevention strategies, such as encouragement, discussions of the benefits of quitting, and assessment of potential challenges to staying quit, should be used with
Answer: Former tobacco users, in particular those who have quit recently
Clinicians should provide brief, effective relapse prevention treatment to all patients who have recently quit tobacco use. Minimal relapse prevention consists of congratulating success, encouraging continued abstinence, and discussing the benefits of quitting, the problems encountered during quitting, and the anticipated challenges to staying quit (eg, alcohol, weight gain, stress, and other tobacco users in the household).
Case Study: Tonya

Tonya is a 22-year-old woman who presents at the clinic for a pre-employment physical. She has never been hospitalized and has no current medical problems. Her birth parents are both living and are in apparent good health. She is unmarried with no children. She is concerned about her weight and performs aerobic exercises 3-4 times weekly. She is 5′3″, weighs 120 lb, BP 126/70, pulse 66. Smoking history indicates that she has smoked 20-25 cigarettes per day for 5 years, and smokes her first cigarette 1-2 hours after waking. She tried to stop smoking 1 year ago but relapsed after gaining 7 lb. She states that she feels that being overweight is as bad for her as smoking. Tonya is starting a new job in 2 weeks in a smoke-free office. She would like to stop smoking and has some confidence in her ability to stop.

Which of the following interventions would be most appropriate in assisting Tonya with quitting?
Answer: Consider the use of cessation medications that delay weight gain
For former smokers concerned with weight gain, the clinician should maintain the patient on medication known to delay weight gain (eg, bupropion sustained-release (SR) and nicotine replacement therapy, particularly 4 mg nicotine gum and lozenge). The clinician should also recommend starting or increasing physical activity, reassure the patient that some weight gain after quitting is common and is usually self-limiting, emphasize the health benefits of quitting relative to the health risks for modest weight gain, emphasize the importance of a healthy diet and active lifestyle, suggest low-calorie substitutes, and refer the patient to a nutritional counselor or program.
Case Study: Jackson

Jackson is a 32-year-old man who comes to the clinic with a sore throat x 1 week, and also complains of muscular aches and pains. He has an unremarkable medical history. His mother has adult-onset diabetes and his father has hypertension. He is married with 3 children. Findings on physical exam: temperature 99.9°, BP 146/88, pulse 80, respirations 18. Throat slightly erythematous. Jackson smokes 1.5 packs per day and smokes his first cigarette immediately upon rising. He has no previous quit attempts. He is not interested in stopping but is somewhat confident that he could if he tried.

Which of the following statements is NOT true regarding the intensity of providing treatment for Jackson?
Answer: Only intensive treatment programs are effective
The longer the session length, the more overall person-to-person contact, and the greater the number of visits, the more successful the treatment outcome. However, even a minimal intervention, lasting less than 3 minutes, can significantly increase overall tobacco abstinence rates.
Which of the following approaches would be MOST helpful to motivate Jackson to consider quitting smoking?
Answer: Provide a motivational intervention designed to enhance future quitting
Patients unwilling to make a quit attempt during a visit may lack information about the harmful effects of tobacco use and the benefits of quitting, may lack the required financial resources, may have fears or concerns about quitting, or may be demoralized because of previous failed quit attempts. Such patients may respond to brief motivational interventions on the basis of principles of motivational interviewing.
Case Study: Sam

Sam is a 71-year old man currently hospitalized with a diagnosis of emphysema. He has been treated for coronary artery disease since age 50 with statins and daily aspirin. Over the past several years, he has experienced mild dyspnea with exercise, which he has attributed to “aging”. He was admitted following complaints of worsening dyspnea and increased cough with yellow sputum production for the last several months. A 100 pack-year smoker, he has tried to quit numerous times in the past and once succeeded in not smoking for a full year. His physical exam demonstrated mild tachypnea and lungs that demonstrate ronchi. He is obviously worried about this hospitalization and suggests to his doctor that maybe his smoking is responsible for his worsening health; but he feels that it is too late for him to try quitting.

Which of the following strategies would be MOST appropriate for Sam?
Answer: Provide assistance, encouragement to quit, and cessation medication while hospitalized and arrange for followup before Sam’s discharge
It is vital that hospitalized patients attempt to quit using tobacco because tobacco use may interfere with their recovery and overall health. Hospitalized patients may be particularly motivated to make a quit attempt, and clinicians should take advantage of this “teachable moment.”
Which one of the following drugs has been found to be safe and effective for the treatment of tobacco dependence and has been approved for that use by the US Food and Drug Administration (FDA)?
Answer: Nicotine patch
FDA-approved medications for treating tobacco use include bupropion SR, nicotine gum, nicotine inhaler, nicotine lozenge, nicotine nasal spray, the nicotine patch, and varenicline. Nortriptyline, nicotine sublingual tablet, and clonidine are sometimes used for smoking cessation but are not approved by the FDA.
Case Study: Grace

Grace is a 3 year-old whose mother brings her to the pediatric nurse practitioner because of recurrent upper respiratory infections and several episodes of a nonproductive cough in the past month after Grace is in bed. Grace has had no hospitalizations or emergency department visits. She has met developmental milestones and appears happy and healthy. Vital signs are: temperature 98.6 F, respiratory rate 17, heart rate 82, and BP 118/60. Chest sounds are clear. Family history reveals that that both of Grace’s parents smoke, both inside and outside of the house and, occasionally in the car.

Which of the following would be an appropriate strategy at this time?
Answer: Provide information on secondhand smoke exposure and offer the parents help in preparing for a quit attempt
Secondhand smoke is harmful to children. Cessation counseling delivered in pediatric settings has been shown to be effective in increasing abstinence among parents who smoke. Therefore, to protect children from secondhand smoke, clinicians should ask parents about tobacco use and offer them cessation advice and assistance.

Written by: adminDiabetes in African Americans

1. According to data from the Diabetes Prevention Program (DPP), which of the following statements regarding racial disparities in A1C among whites vs populations of color (Hispanic, American Indian, Asian, Black) is true?
Racial disparities in A1C among whites vs populations of color do not exist.
They are marginal.
They exist, but are not clinically significant.
They are drivers of poorer outcomes.
They are not a therapeutic issue.
2. Which of the following statements is true about insulin sensitivity among ethnic groups?
It is highest among non-Hispanic whites.
It is highest among African Americans.
It is highest among Asian Americans.
It is highest among Mexican Americans.
Differences have not been found among ethic groups.
3. According to the landmark United Kingdom Prospective Diabetes Study (UKPDS), how much beta-cell function is lost at the time of a type 2 diabetes diagnosis?
10%
25%
50%
75%
100%
4. Racial/ethnic disparities have been found under which of the following parameters?
Across healthcare settings
Across disease areas
Across clinical settings
Across healthcare settings, disease areas, and clinical settings
No racial disparities have been found under these parameters.
5. Which of the following is not considered a diabetes management challenge for the clinician treating the African American population?
Identify the high-risk patients and use preventive strategies, especially in the obese.
Attempt to alter the natural history of disease.
Apply more intensive therapy using the full spectrum of combination treatments.
Reserve the use of insulin therapy for only the most severe of patients.
Employ a more integrative approach to offset impact of cultural barriers.
6. What is the percentage of patients from the UKPDS who required the addition of insulin to control blood glucose to target goal at 5 years post-oral therapy?
10%
20%
30%
40%
100%
7. Which of the following is not true about medical nutrition therapy (MNT)?
MNT outcomes can be seen immediately (within the first 2 weeks).
MNT can result in a 1% to 2% decrease in A1C in type 2 diabetes.
The pleasure of eating must be maintained with MNT.
MNT must be culturally sensitive and individualized.
MNT can reach a point where it is no longer of benefit to the patient.
8. Which of the following insulins has an action profile appropriate for use as a basal insulin?
Aspart
Lispro
Glulisine
NPH
Glargine
9. Which of the following is not considered a barrier to insulin therapy?
Weight gain
Fear of needles
Patient age
Fear of hypoglycemia
Physician’s fear of alienating a patient
10. Which of the following statements accurately describes a main concern about the use of insulin therapy?
It is used too aggressively.
It is used too soon.
It is used too late.
It is used for short periods.
It is used too broadly across groups.

Answers:

According to data from the Diabetes Prevention Program (DPP), which of the following statements regarding racial disparities in A1C among whites vs populations of color (Hispanic, American Indian, Asian, Black) is true?
Answer: They are drivers of poorer outcomes.
The DPP estimated the racial differences in A1C levels compared with the white population. Baseline A1C tended to run higher in the populations of color compared with the white population. This is evidence that, at the start, there are forces at work that are driving poorer outcomes (poor control = poor outcomes) in these communities. In other words, racial disparities in A1C among whites vs populations of color are a driver of poorer outcomes.

Which of the following statements is true about insulin sensitivity among ethnic groups?
Answer: It is highest among non-Hispanic whites.
A study of insulin sensitivity among healthy subjects provides a glimpse of one of the major reasons why there is more diabetes in communities of color. There is less insulin sensitivity in African Americans, Asian Americans, and Mexican Americans compared with non-Hispanic whites; that is, there is more insulin resistance in these communities. As a result, there are more diagnoses of type 2 diabetes in communities of color, in children as well as adults.

According to the landmark United Kingdom Prospective Diabetes Study (UKPDS), how much beta-cell function is lost at the time of a type 2 diabetes diagnosis?
Answer: 50%
According to the landmark UKPDS trial, 50% of beta-cell function is already lost at the time of type 2 diabetes diagnosis. Consequently, it is a challenge to change the natural history of type 2 diabetes, to alter this deterioration of beta-cell function.

Racial/ethnic disparities have been found under which of the following parameters?
Answer: Across healthcare settings, disease areas, and clinical settings
One major problem in the treatment of type 2 diabetes among various racial/ethnic groups is the application of unequal treatment among these groups. Ethnic disparities have been consistently found across a wide range of healthcare settings, disease areas (including diabetes), and clinical services. Countering this unequal treatment can go a long way towards improved control of type 2 diabetes and its complications among ethnic groups.

Which of the following is not considered a diabetes management challenge for the clinician treating the African American population?
Answer: Reserve the use of insulin therapy for only the most severe of patients.
The diabetes management challenges for the African American population include the following:
Identify the high-risk patients and use preventive strategies, especially in the obese.
Apply intensive management strategies to reduce the impact of risk factors.
Attempts to alter the natural history of disease are warranted.
More intensive therapy using the full spectrum of combination treatments is required in African Americans.
Employ a more integrative approach to offset impact of cultural barriers.

What is the percentage of patients from the UKPDS who required the addition of insulin to control blood glucose to target goal at 5 years post-oral therapy?
Answer: 40%
In the UKPDS, investigators found that after initiating treatment for diabetes with a sulfonylurea, nearly 10% of patients required the addition of insulin to control blood glucose to the target goal during the first year. By 5 or 6 years, 2 out of 5 patients (40%) needed insulin. UKPDS showed that, rather than positioning insulin as a late tool for diabetes management, the requirement of insulin supplementation was rather early in the course of type 2 diabetes.

Which of the following is not true about medical nutrition therapy (MNT)?
Answer: MNT outcomes can be seen immediately (within the first 2 weeks).
MNT modifies nutrient intake and lifestyle, aiming at normalizing A1C, blood pressure, and cholesterol (the ABCs), in order to prevent or slow the progression of diabetes and its complications. MNT can result in a 1% to 2% decrease in A1C in type 2 diabetes. MNT outcomes can be seen in 6 weeks to 3 months. To be successful, the pleasure of eating must be maintained with MNT, and it must be a culturally sensitive and individualized plan. There does come a time when MNT alone may no longer be of benefit to the patient, at which time adding pharmacologic treatment is necessary.

Which of the following insulins has an action profile appropriate for use as a basal insulin?
Answer: Glargine
Glargine and detemir are basal insulins. Their onset of action is in 1 to 2 hours, they have a flat peak of action and a duration of action of about 24 hours.

Which of the following is not considered a barrier to insulin therapy?
Answer: Patient age
Weight gain, fear of needles, and fear of hypoglycemia, among others, are all patient-related factors that serve as barriers to use of insulin. Physicians themselves may have their own barriers to using insulin in a patient, one of which is a fear of alienating or even losing that patient. Patient age by itself is not a barrier to insulin use.

Which of the following statements accurately describes a main concern about the use of insulin therapy?
Answer: It is used too late.
Insulin is fairly widely used in the United States, but it is considered as not being used early enough. In addition, although insulin is used fairly freely, there may be evidence that it is not intensified with equal opportunity. In a study comparing 3 major ethnic groups in the country, those for whom insulin was intensified to 2 or more injections per day were more likely to be non-Hispanic whites versus non-Hispanic blacks.

Written by: adminEffects of Maternal Tobacco-Smoke Exposure

1. Which of the following statements about maternal smoking and birthweight is most accurate?
Younger smokers are at the highest risk for intrauterine growth restriction (IUGR)
The effect of smoking in reducing birthweight is not noted among women with a higher body mass index
Cigarette use in the third trimester appears to have the strongest relationship with birthweight
Although smoking increases the risk for IUGR, there is no dose-response relationship between maternal smoking habits and birthweight
2. Maternal smoking is least likely to negatively affect which of the following measures among newborns?
Subcutaneous fat
Head circumference
Limb length
Weight
3. Which of the following statements about fetal ultrasound among women who smoke is most accurate?
Smoking does not appear to affect fetal organ size
Research has yet to demonstrate an effect between maternal smoking and fetal long bone length
Research has yet to demonstrate an effect between maternal smoking and fetal head measurements
Women who smoke during pregnancy should routinely be assessed with ultrasound early in the third trimester
4. Which of the following statements about smoking cessation during pregnancy is most accurate?
Smoking cessation has not been associated with an increase in birthweight
Intervention programs can improve rates of smoking cessation by 50%
Smoking cessation during the first trimester promotes similar neonatal outcomes compared with smoking through the third trimester
Reducing the number of cigarettes consumed appears as effective as smoking cessation in improving birthweight

Answers:

Which of the following statements about maternal smoking and birthweight is most accurate?
Answer: Cigarette use in the third trimester appears to have the strongest relationship with birthweight
There is a synergistic effect between older maternal age and smoking in promoting IUGR. Body mass index does not mitigate the effects of smoking in reducing birthweight, and an inverse dose-response relationship has been demonstrated between maternal smoking habits and birthweight.

Maternal smoking is least likely to negatively affect which of the following measures among newborns?
Answer: Subcutaneous fat
Previous research has found that maternal smoking predominantly lowers newborn weight, limb length, and head circumference. However, maternal smoking appears to leave measures of subcutaneous fat in newborns relatively unchanged.

Which of the following statements about fetal ultrasound among women who smoke is most accurate?
Answer: Women who smoke during pregnancy should routinely be assessed with ultrasound early in the third trimester
Maternal smoking has been associated with reduced renal and cardiac volume, reduced long bone length, and reduced biparietal and occipitofrontal diameters on fetal ultrasound. Therefore, ultrasound should be routinely performed during the early third trimester among women who smoke.

Which of the following statements about smoking cessation during pregnancy is most accurate?
Answer: Intervention programs can improve rates of smoking cessation by 50%
Smoking cessation is associated with improved birthweight, and women who quit smoking cessation during the first trimester have similar anthropometric neonatal outcomes compared with never-smokers. Smoking cessation is more effective than reducing cigarette consumption in improving birthweight.